EnBase is once again featured in a Scientific Publication

March 19, 2010

Scale-down simulators for metabolic analysis of large-scale bioprocesses Peter Neubauer and Stefan Junne

We hope you enjoy reading this article from the TU Berlin which features the use of EnBase our congratulations to Peter and Stefan
http://www.ncbi.nlm.nih.gov/pubmed/20185293

Scale-down simulators for metabolic analysis of large-scale bioprocesses.
Neubauer P, Junne S.

Technische Universität Berlin, Institute of Biotechnology, Department of Bioprocess Engineering, Ackerstr. 71-76, D-13355 Berlin, Germany.
Analytical approaches for a comprehensive understanding of the metabolic networks in microbial cultures are mostly based on small-scale cultures which are in a steady state or undergo dynamic changes. For drawing conclusions to industrial-scale bioprocesses, however, it is important to understand that cells in large-scale bioreactors are exposed steadily to fast changes, because of an inhomogeneous environment. Analytical approaches that aim for large-scale bioprocess understanding need to apply specific laboratory simulators. Recent developments in cell cultivation techniques and computational tools provide improved possibilities to evaluate how a process will behave in the final scale. These simulators will pave the way for screening robust strains and process conditions. Copyright © 2010 Elsevier Ltd. All rights reserved.